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For the fungus (Candida glabrata and Candida Parapsilosis), glutathione is also a virulence factor, helping the yeast resist oxidative stress and antifungal drugs
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The reason this stood out for me is because when I looked up Pickart, he has been working on this molecule for decades
These differences influence not only how they are clinically trialed but also how they are prescribed and covered by insurance
This tolerance development explains why side effects are most prominent during treatment initiation and dose escalation but decline substantially with continued use
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