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Concerning reactions include: spreading redness beyond a 2-inch radius from the injection point (possible cellulitis), warmth that persists beyond 24 hours with worsening tenderness (possible abscess formation), pus or cloudy discharge from the injection site (infection), red streaks extending from the site toward the torso (lymphangitis), or systemic symptoms like fever above 100.4F within 48 hours of injection

Phase 3 studies using mazdutide as obesity treatment in a Chinese population (doses between 4 and 9 mg) are also ongoing (NCT05607680, NCT06164873)