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Studies in various in vitro models often focus on its influence on the expression of genes related to angiogenesis, such as the Vascular Endothelial Growth Factor (VEGF) signaling pathway, and its effects on cellular repair mechanisms
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In the pivotal SURMOUNT-1 trial involving adults without diabetes, participants receiving the highest dose (15 mg) lost an average of 20.9% of their body weight over 72 weeks, compared to 3.1% with placebo
Philips et al
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