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Beyond gastrointestinal symptoms, other adverse effects observed in trials include injection site reactions (such as redness, bruising, or mild swelling), fatigue, dizziness, and small mean increases in heart rate
Structural improvements in range of motion and tissue resilience become apparent from weeks three to four
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Mazdutides dual GLP-1/glucagon mechanism is structurally different from tirzepatides GLP-1/GIP combination, and its reported weight-loss figures (up to 16.65% at 60 weeks) sit closer to semaglutides range in its published trials to date, though its trial population and duration differ from the semaglutide and tirzepatide programs
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