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Methods Study design The SEMPA trial (Effect of Empagliflozin and Semaglutide on Cardio-Renal Target Organ Damage in Patients with Type 2 Diabetes A Randomized Trial) was a 32 week investigator-initiated, randomised, partly placebo-controlled, partly open-label trial, designed to assess the separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and arterial stiffness as two co-primary outcomes
Effects of vildagliptin twice daily vs
This study aimed to critically assess the existing literature on the adverse effects of GLP-1 RAs to formulate appropriate risk-benefit prescription practices for their optimal utilization as metabolic disease therapeutics
Although the liver carries out most of the metabolising of drugs that enter the system, the renal system must also function properly in order to clear out the semaglutide from the body, leading to reduced systemic exposure to the drug
GLP-1 drugs began being approved by the US Federal Drug Administration for use in Type 2 Diabetics in 2005.[3] Their impact has been tremendous
