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In mice, TLCA activates TAS2108 at 1 M, and TLCA activates TAS2144, whereas LCA activates TAS2105 at 3 M

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The history of GLP-1Ra started in 2005 with exenatide (Byetta) developed by Amylin Pharma and Eli Lilly being the first GLP-1Ra to be approved on the market in 2005

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