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Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine
EMBO J 17:71517160
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These include traction alopecia, androgenic alopecia, and hyperthyroidism, among others
Most cosmetic actives have a 10-fold to 100-fold therapeutic window
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