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According to the press release, the safety profile of orfoglipron was similar to injectable GLP-1 drugs, like Zepbound and Mounjaro

Another TKI, gefitinib (ZD1839, Iressa), which targets the epidermal growth factor receptor (EGFR), has been shown to restrict M.tb replication in both macrophages as well as in the lungs of M.tb -infected mice by promoting the host autophagy pathway through the inhibition of the p38 MAPK signaling pathway activated by EGFR [10]

Greater waist circumference reduction at week 20 was associated with lower subsequent MACE risk, suggesting that reduction in central adiposity (visceral fat around the organs) may contribute to cardiovascular protection

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At the same time, isolated case reports and safety surveillance entries have described deep vein thrombosis and pulmonary embolism after starting Tirzepatide, and studies of similar drugs have raised questions about clot risk