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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference
The recommendations from the workshop were just published in the medical literature: Recommendations for real-world evidence of efficacy and safety of GLP-1 agonists in Prader-Willi syndrome: Report of a workshop held by the Foundation for Prader-Willi Research and International Prader Willi Syndrome Organisation The experts agreed on the urgent need to collect detailed real-world data from individuals with PWS who are prescribed GLP-1s
Davletova et al., 2005)
Thats why its always smart to talk with your doctor about your personal health risks before taking GLP-1 drugs for weight loss, especially if you have any other health condition or are taking other medications
Low glutathione levels alert us to oxidative stress and point to an underlying cause of psychosis and major depressive disorder
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