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The transport of L-lactate is mainly mediated by MCT1 and MCT2, which facilitate its influx from the extracellular space, while MCT4 promotes its efflux, regulated by the lactate concentration gradient [40-42]

In aged mice, treatment with 5-amino-1mq combined with exercise produced remarkable results

It helps transform fat into energy, supports heart and brain function, and enhances exercise recovery

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On the other hand, the treatment policity estimand was used to evaluate the treatment effect for all randomized participants regardless of whether the trial was discontinued early or rescue medicien was used [2]