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Modern pharmacologic approaches allow quantitative receptor engagement to be balanced, mitigating liabilities while preserving efficacy ( Oxyntomodulin, therefore, occupies an important conceptual position in this review
With macrogol preparations, starting with one sachet daily and increasing to two or three sachets based on response is a sensible approach
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Nebulization of AAT proved to be a suitable administration strategy ready to be translated to the clinical practice for direct lung delivery of the protein in AATD patients, either as a support therapy to parenteral administration or, for subjects with a precocious diagnosis, as a means to prevent the onset of pulmonary symptoms
doi:10.12688/f1000research.20906.1
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