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Dabaja AA, Schlegel PN

Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

High levels of polyamine pools are maintained by increased biosynthesis, transport, and inhibition of catabolism, with the involvement of numerous oncogenes (Myc, Jun, Fos, and Kras) [264]

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Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds