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In any event, TRIP12 regulates NF-B activity by limiting the steady-state OTUD5 protein level before TNF- stimulation, unlike other E3s regulating NF-B signaling such as LUBAC, TRAFs, and cIAP1, which are transiently activated to directly ubiquitylate the NF-B cascade regulators through K63- or M1-linked chains 46

Keratography results indicated substantial enhancements in tear break-up time and tear meniscus height posttreatment

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