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For instance, recent studies in mouse models have revealed that astrocytes maintain an intracellular lactate reservoir that can be rapidly mobilized in response to neuronal cues such as elevated extracellular K + or membrane depolarization

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3.2 Necroptosis of tubular epithelial cell in DKD Transcriptomic and single-nucleus RNA sequencing analyses have demonstrated significant enrichment and perturbations of the necroptosis pathway in diabetic kidney tissues, highlighting its core role in driving tubulointerstitial injury (135)

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