GLP-1s Approved in Europe (Wegovy, Saxenda, Mounjaro)GLP-1s Approved in Europe (Wegovy, Saxenda, Mounjaro) Several GLP-1 medicines are now approved in Europe to help with weight management
it is frequently comorbid with hypertension, dyslipidemia, fatty liver disease, and sleep apnea
Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment in Adults With Early Syphilis: Secondary Analysis of a Randomized Clinical Trial
In one study, 12-week treatment with insulin glargine vs liraglutide (mean dose = 1.3 mg/day) showed similar glycemic control and decrease of hepatic fat burden, although a reduction in BMI was only observed in the liraglutide-treated patients (68)
In contrast, another study demonstrated that transgenic mice with a beta-cell specific deletion of the GLP-1R have impaired intraperitoneal (ip) glucose tolerance but maintain normal oral glucose tolerance (Smith et al., 2014)