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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

Nemoto, N., Miyamoto-Sato, E., Husimi, Y

It also aids in producing proteins and chemicals that your body needs for several processes

4.7 Iron Iron concentration is regulated by the hepcidin/ferroportin axis: liver hepcidin binds to tissue ferroportin, causing its internalization, blocking iron export, and therefore lowering serum concentration

Scientific References Frequently Asked Questions Can I have B12 injections more frequently if symptoms return early