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Mechanisms of Action-Mediated DDIs Furthermore, assessing DDIs for GLP-1 RAs and a dual GLP-1/GIP RA requires additional considerations, including the possible occurrence of DDIs mediated by mechanisms of action that remain poorly understood (Figure 3)

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It was also noted that in comparison to a 1.2 mg dose of the active control, doses of semaglutide ranging from 0.8-1.6 resulted in a greater reduction in fasting plasma glucose