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From a kidney disease event reduction standpoint, SGLT-2s will be tough competitors for Ozempic and other GLP-1s to beat
According to FDA labeling, nausea occurs in approximately 44% of patients on Wegovy (2.4 mg for weight management) and 15-20% on lower diabetes doses, with vomiting, diarrhea, constipation, and abdominal pain also common
doi: 10.1016/j.ejphar.2022.175029 53 WangX-CGusdonAMLiuHQuS
Heres what I conclude: GLP-1 microdosing and off-label use occupy an uncomfortable gray zone - strong mechanistic rationale, consistent observational patterns, but limited controlled human data