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Brand names include Zepbound (approved for weight loss) and Mounjaro (approved for type 2 diabetes)

Real-world GLP-1 RA therapy in type 2 diabetes: a long-term effectiveness observational study

et al., 2020

4), aside from increased 5-HT reuptake in astrocytes, increased oxidative and nitrosative stress leads to activation of indoleamine 2,3-dioxygenase (IDO), and increased proinflammatory cytokines activate tryptophan 2,3-dioxygenase (TDO) [318]

The present analysis showed that injection site had a small effect on the bioavailability of semaglutide, which was lower following injection in the thigh compared to abdominal injection