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Certainty of evidence was assessed using the key factors of study quality, consistency, and precision

Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants

This mechanistic depth is the basis for Phase 2 outcomes that exceeded all prior single- or dual-agonist research

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As our understanding of HFpEF evolves, GLP-1RAs have the potential to become a cornerstone of therapy, addressing the multifactorial nature of this condition and improving outcomes in a challenging patient population