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Patients considering low-dose GLP-1 therapy should undergo thorough evaluation, including assessment of contraindications, baseline inflammatory markers if appropriate, and regular monitoring for adverse effects
This creates a strong incentive to maintain treatment, even in the face of inconvenience or mild side effects
Standard dosing suggests one capsule twice daily on an empty stomach
Fitness tracks with survival about as strongly as anything we can measure: in a study of over 120,000 people given an actual treadmill test, the least fit died at dramatically higher rates, and the steepest gains came at the bottom, from simply moving off the couch (Mandsager et al., 2018)
CBT-I (Cognitive Behavioral Therapy for Insomnia) Mechanism: Behavioral/psychological intervention with the strongest long-term evidence for chronic insomnia
