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FIGURE 7 The strong role of severe oxidative stress, reduced antioxidant defenses like GSH with increased lipid peroxidation and malondialdehyde generation (213), lipid, protein and DNA oxidation with increased apoptosis and necrosis in atherosclerosis as a major cause of cardiovascular diseases and stroke, supports the use of complementary and alternative medicines, dietary supplements, and antioxidants with hardly any adverse effect, able to restore homeostasis reversing oxidative stress (214)
As part of its wound healing effect, GHK-Cu has been shown to contribute to the initial upregulation of growth factors and inflammatory mediators during nerve regeneration [8]
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