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15.6% with semaglutide Trial REDEFINE 1 (NEJM 2025) Duration 68 weeks Population Obesity, no T2D (n=3,417) Mean Weight Loss 11.8% cagrilintide alone
Skin inflammation Decreases inflammatory discoloration, redness, and blotchy patches by neutralizing free radicals
Experimental Dermatology, 34 (2), e70042
Pentoxifylline in diabetic kidney disease (VA PTXRx): protocol for a pragmatic randomised controlled trial
For those with significant hyperpigmentation or very dark skin tones, the most dramatic results often appear after 6 months of dedicated use
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