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In high-fat-diet rodent models, changes in body mass or adipose-tissue measurements may reflect the experimental metabolic endpoint being studied, but safety interpretation is stronger when paired with food intake, body composition, activity, general observations, serum chemistry, hematology, organ weights, and histopathology

Spijkers, J

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Mechanism snapshot Positioned within NNMT inhibitor-class research for metabolic and methylation-linked pathways, distinct from NMN replacement biology

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