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doi: 10.26355/eurrev_202310_34169 Chen AS, Batsis JA

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A person who stops because coverage disappears is not answering the same question as a person who stops because of adverse effects, inadequate benefit, a planned interruption, or personal preference

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It says microbial contamination becomes a concern once a vial has been open beyond the recommended 28-day window or has been stored improperly