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239 Treatment with MAT2A inhibitors AG-24152 and AG-270 significantly reduces SAM levels, inhibits PRMT5 activity, and causes DNA damage and mitotic defects in tumor cells
The potential for ADA development with BLV treatment was assessed in an integrated analysis of results from 2 Phase 2 studies (MYR203, MYR204) and 1 Phase 3 study (MYR301)
10.1186/s13054-022-04090-1 114 ZongQ.QuH.ZhaoY.LiuH.WuS.WangS.et al (2022)
Also, its slightly slower than intramuscular administration
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