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Despite the drugs cardiovascular benefits, both trials found no significant difference in retinopathy outcomes between the GLP-1RAs and placebo groups
Irisins role in glucose homeostasis and exercise metabolism
As mentioned above, GLP-1R signaling plays a natriuretic role to modulate Na + balance and prevents volume expansion (95)
The STEP 1 trial showed an average weight loss of 14.9% of body weight at this dose over 68 weeks
Varied results have been obtained, and more robust and larger-scale RCTs are necessary to draw definitive conclusions
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