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As an accumulation of DNA methylation of intrinsic factors, such as Sox 2, NeuroD 1 and NeuroD2 , has been detected in cultured astrocytes and in the aged cortex (Siegmund et al., 2007
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It is also increasingly apparent that this issue is not going away anytime soon
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Metabolic dysfunction and the development of physical frailty: an aging war of attrition
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