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The dose-limited side effects for shorter-acting agents such as exenatide, lixisenatide, and liraglutide are largely gastrointestinal in nature

Hormones (Athens) 21(1):4149 Polyzos SA, Kang ES, Boutari C, Rhee E-J, Mantzoros CS (2020) Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

The calculator can explain the math, but it cannot tell you which dose is appropriate or whether you should change your treatment plan

[1] [3] Common adverse effects include gastrointestinal symptoms such as nausea, diarrhea, vomiting, and constipation, which typically diminish over time