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Research documents that endothelial cells at injury sites produce SPARC protein containing GHK sequences, which upon breakdown releases GHK-containing peptides that stimulate cell proliferation and new vessel growth

At 0.25 mg, steady-state concentration is still modest

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The trial product estimand evaluates the treatment effect for all randomised patients under the assumption that all patients remained on the trial product for the entire planned duration of the trial and did not use rescue medication

The elution was concentrated using an Amicon Ultra Centrifugal Filter (MWCO 100 kDa) and subjected to size-exclusion chromatography (SEC) on a Superdex 200 Increase 10/300 column that was pre-equilibrated with 20 mM HEPES pH 7.4, 100 mM NaCl, 2 mM MgCl 2 , 1 M peptide, 0.01% (w/v) LMNG and 0.0006% (w/v) CHS