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At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off

Therefore, GIP functions as a bifunctional regulator that stabilizes blood glucose and has diverging, glucose-dependent effects on the two main pancreatic glucoregulatory hormones (Christensen et al., 2011)