The British Journal of Nutrition
Even in animal studies, tiny doses have been effective, so no need to go overboard
Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers
Exclusion criteria for all groups included current or previous psychiatric comorbidities as diagnosed by DSM-5, using a structured interview (The Structured Clinical Interview for DSM-5, SCID-5) [28] if deemed relevant by the investigator, any general medical conditions known to influence energy processing and/or linked to fatigue, current treatment with any medication/supplementation likely to interfere with energy metabolism if deemed relevant by the investigator, contra-indications to magnetic resonance (MR) imaging, pregnancy or breast feeding
In comparison with the TAA group, the 25-mg/kg dose reduced MDA by 50.2% and increased GSH and SOD by 38.8% and 229.2%, respectively