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Importantly, Akt/PKB also phosphorylates forkhead transcription factors of the FOXO subfamily, and this leads to their inactivation and retention in cytoplasm[254, 255] resulting in a reduced transcriptional activity[256]
The compelling rat data cannot substitute for that
More physical therapy
Thus, unlike for MACE, the effect of GLP-1RAs in reducing the risk of HHF has not yet been consistently demonstrated in individual trials
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