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Absence of Herb-Drug Interactions of Mistletoe with the Tamoxifen Metabolite (E/Z)-Endoxifen and Cytochrome P450 3A4/5 and 2D6 In Vitro

Some individuals use this combination with the aim of supporting physical performance or weight management, though clinical evidence supporting such benefits remains limited

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Regarding weight loss, the FDA has approved these drugs for people whose body mass index (BMI) is greater than 30 kg/m2, or they have a BMI that is greater than 27 and have a weight-related health problem, such as high blood pressure, sleep apnea, or pre-diabetes