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45.3% of participants on the highest dose lost 30% or more of their body weight TRIUMPH-4 knee osteoarthritis + obesity (Dec 2025) 28.7% weight loss at 68 weeks TRANSCEND-T2D-1 type 2 diabetes (Mar 19, 2026) A1C -2.0%, 16.8% weight loss at 40 weeks TRIUMPH-2 obesity with type 2 diabetes, nested OSA protocol (July 23, 2026) 20.8% weight loss at 12 mg over 80 weeks

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You also dont want to flush out remaining electrolytes by adding a large amount of plain water to your daily routine

What this means for retatrutide in Australia Retatrutide is still undergoing multiple phase 3 clinical trials, the biggest of which is TRIUMPH-3

These SCFAsparticularly butyrate, propionate, and acetatebind to receptors on L-cells, triggering GLP-1 release