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Discontinuing a prescribed medication without your doctors advice can result in injury or death

The most cited discontinuation data point is real: in the STEP 1 trial extension , one year after stopping semaglutide 2.4 mg, participants regained about two thirds of their prior weight loss, and cardiometabolic improvements drifted back toward baseline

The peptide stack calculator helps determine compatible combinations and timing

Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect

For a full list of side effects: Side effects are typically mild and go away over time