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Pharmacological intervention with rosiglitazone, an ACSL4 inhibitor, led to a 44% reduction in 4-hydroxynonenal (4-HNE) levels and a 42% decrease in A plaque deposition in brain tissues
This results in prolonged satiety and decreased hunger cravings, which leads to weight loss
Blood glucose levels were measured at the same time points using a commercially available ELISA kit (IBL Japan)
Likewise, our in vitro study showed that GLP-1R protein level in HUVECs was significantly decreased after exposure to PA for 24 h
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