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In light of this potential significant safety issue, the development of Lotiglipron has been discontinued, meaning the drug did not progress to further clinical trial stages to evaluate its efficacy and safety
Despite more than 500 published preclinical studies (primarily animal and cell-culture models from Sikiric and colleagues at the University of Zagreb), there have been essentially no registered human clinical trials for BPC-157 in the United States
Where evidence is absent, that gap is stated plainly
How does the liver metabolise drugs
doi: 10.3390/ph19020235
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