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Also GLP1RAs have been found to decrease epicardial fat, which may help explain their potential in lowering the risk of atherosclerosis

For a while, these medicines were only available as injections, but the introduction of a GLP-1 in pill form, Rybelsus, has given patients a needle-free Ozempic alternative

The optimal injection timing can vary between patients, and some find that morning injections versus evening injections make a significant difference in sleep quality

Beyond that, a head-to-head comparison from the SURMOUNT-5 trial illustrates the difference clearly: Participants taking tirzepatide lost an average of 20.2% of their body weight compared to 13.7% with semaglutide