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these include the patients in the reference population who did not have a diagnosis ( n = 69) or patients with IEMs that are not typically treated with l-carnitine supplementation (e.g., guanidinoacetate methyltransferase deficiency (OMIM612736

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The biological mechanism isnt fully understood, but GLP-1s reduce systemic inflammation and may influence reward pathways in the brain both relevant to psychiatric conditions

doi:10.1016/j.cmet.2022.07.013 Source for half-life approximately 6 days, once-weekly dosing pharmacokinetic rationale, and approximately 95% subcutaneous bioavailability

33 An international phase III RCT (RESOLVE-IT, NCT02704403) comparing elafibranor with placebo in NASH patients was terminated early due to insignificant efficacy but without significant adverse events at 72 weeks of treatment