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doi: 10.1016/0091-3057(91)90568-m 140 LakattaE
The four TM helices of zDHHC20 adopt a tepee-like organization in the membrane, and the residues lining this cavity determine the acyl-CoA chain length selectivity of the enzyme
& Gladwin, M
By activating the cGMP/PKG signaling pathway, it can reversibly and locally open the tight junctions of intestinal epithelial cells, thereby enhancing drug delivery efficiency by 3.5-fold and achieving a therapeutic efficacy of 98.6% in treating CRC
De cette manire, sa stabilit et son absorption sont amliores, optimisant ses effets dans l'organisme
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