Compounding is legally permitted but involves a trade-off between cost and the regulatory oversight that comes with FDA-approved medications
10.1111/j.1463-1326.2010.01313.x 50
Mads Krogsgaard Thomsen, at the time R&D executive in the Diabetes Care Division of Novo Nordisk, undertook the initiative to synthesize long-acting GLP-1 analogues (Fig
Clinical trial data provides objective evidence about efficacy (24.2% weight loss at 48 weeks), safety (88.8% completion rate), side effects (peak at weeks 6-8, resolve by week 12 for most), and discontinuation outcomes (70-80% regain over 12-18 months, not immediately)
However, this effect is less pronounced in alcohol-dependent rats, possibly because their systems are already desensitized