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Tirzepatide affects gastric emptying, which can alter the absorption of oral medications including insulin, sulfonylureas, oral contraceptives, and narrow therapeutic index drugs like warfarin

Once in use, it can be kept at room temperature for up to 28 days

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MC3R plays a supporting role MC3R knockout mice show altered adiposity and altered sensitivity to high-fat diet but a milder obesity phenotype than MC4R knockouts