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We proposed the assessment of 6-sulfatoxymelatonin (aMT6s, Figure 2) to detect whether the blockage of noradrenaline neuronal reuptake on the first day of medication took place

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doi: 10.3389/fphar.2025.1737199 Received 01 November 2025 Revised 21 December 2025 Accepted 29 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Dawei Chen, University of Kiel, Germany Reviewed by Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Updates Copyright 2026 Knudsen, Tadje, Coggins and Venketaraman

(7.2) Use In Specific Populations Pregnancy: Based on animal studies, may cause fetal harm