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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)
L.GaleaE.et al (1993)
The blockage generates an environment where bacteria can thrive and trigger inflammatory responses
Jayaprakash N, Elumalai K, Manickam S, Bakthavatchalam G, Tamilselvan P
The peptide is stable in solution at physiological pH (7.2-7.6) but degrades in strongly acidic conditions
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