But one should never use supplements or powders as a replacement for whole foods
GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

This low initial level enables your body to slowly adjust to the medication, reducing the chances of negative reactions
J Toxicol Environ Health 41:387409 Kalyanaraman B, Karoui H, Singh RJ, Felix CC (1996) Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiolsa high resolution ESR spin-trapping study at Q-band (35 Ghz)
The translational silencer DJ-1 loses its affinity to RNA when cysteine residues of the DJ-1 protein become oxidized (Blackinton et al., 2009)