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Consistent with our findings in mice, liraglutide treatment caused a 1.6 logfold increase in PCSK1 expression in the -1 subcluster compared with control (Figure 4, A and B, and Supplemental Figure 4A
If you're also being treated for diabetes, thyroid issues, or heart disease, a weight-loss-only clinic often isn't talking to those other providers
The results speak for themselves
Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )
2025, doi: 10.1001/jama.2025.24288
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