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In a 2021 trial of semaglutides, lean mass was reduced by 6.92kg alongside an overall weight drop of 15.3kg, meaning around 45% of the weight lost came from lean mass, comfortably exceeding the commonly cited quarter fat-free mass rule that predicts about one quarter of weight loss typically comes from lean tissue
The rat studies producing the cardiovascular effects described above used 2 to 10 mcg/kg/day, which in a 70 kg adult would correspond to roughly 140 to 700 mcg/day, providing some rough allometric alignment with compounded doses but not a validated human dose
The FDA-approved obesity-medication landscape still centers on products such as Wegovy, Zepbound, Saxenda, and related prescription options
Even the moral failing argument seems to be receding as more and more people experience success on these medications and societal acceptance increases
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