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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
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When an individual has an MTHFR polymorphism, their body struggles to efficiently convert synthetic cyanocobalamin (the cheap form of B12 found in most standard supplements and fortified foods) into the active methylcobalamin required by the cells
No significant toxicity documented up to high doses in animal studies
Composed of a sequence of 15 amino acids, the peptide can also be found in trace amounts in the gastric fluids of other mammals
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