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In the skin, vitamin C plays a critical role in synthesizing collagen, the protein that provides structure and elasticity
Disclosures: The authors have no conflicts of interest relevant to the contents of this article
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It plays significant roles in energy metabolism and mitochondrial protection
However, the role of FXR in improving metabolic dysfunction is contentious, as intestine-specific FXR agonism improves the metabolic profiles of mice 274,275 and increases the expression of TGR5 276 , which mediates bile acid-induced GLP-1 secretion from EECs 277
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